Dr. Mansoor Khan, CEO of DiagnosisONE, recently met with Mr. Mohammed Mian Soomro, the Prime Minister of Pakistan, to discuss the state of public health in Pakistan and the strategies and tactics that can be adopted to improve delivery of care. DiagnosisONE was recently selected by the Centers for Disease Control (CDC) to develop a National Public Health Information Network in Pakistan. DiagnosisONE’s D1.Surveillance system, which will be operational in Pakistan this year, will help public health officials access, collect and report data about real or potential outbreaks of communicable diseases. Recent public health threats, including an outbreak of bird flu that killed one person in December, have increased the need for integrated disease surveillance. “The Pakistan government is very supportive of efforts to implement an integrated disease surveillance system. This technology will be vital for introducing internationally recognized standards of care to our country,” said Prime Minister Soomro. “The private sector needs to be an integral part of efforts to introduce these capabilities in Pakistan. We commend DiagnosisONE for taking the initiative,” Mr. Soomro said. Prior to the meeting, the Prime Minister visited with Khan in the United States and urged him to come forward and help Pakistan improve the information technology infrastructure related to healthcare, which eventually led to the CDC contract. “We are pleased to introduce a level of healthcare technology that was previously not available to the people of Pakistan. It’s very rewarding to know that the system we’ve implemented will ultimately improve the welfare of millions of people,” Khan said. The new system will, for the first time, also offer an electronic log book consisting of abridged versions of electronic medical records that will be distributed for free to physicians. This resource will allow caregivers to chart patient demographics and health information that can be used to drive care delivery and communicable disease reporting. The D1.Surveillance system is currently used by Puerto Rico, the Massachusetts Bureau of Communicable Disease Control and Prevention, and the Massachusetts State Laboratory Institute. About DiagnosisONE DiagnosisONE, an innovative leader in the healthcare IT industry, develops and markets Intelligent Connectivity Solutions. Those solutions allow customers in clinical and public health environments to collect data from disparate sources, apply clinical and bioterrorism rules to those data, and deliver the resulting information to care providers and decision makers. DiagnosisONE’s customers include the Centers for Disease Control and Prevention, numerous state departments of health, integrated delivery networks, health plans and health systems. For more information, visit the Web site, www.diagnosisone.com.

DiagnosisONE announced today it has been selected by the Centers for Disease Control to develop the IT infrastructure for the national public health system in Pakistan. This effort is expected to bolster the health and welfare of over 160 million Pakistanis many of whom are often exposed to diseases such as hepatitis and typhoid fever. DiagnosisONE’s D1.Surveillance system will also be used to monitor potential disease outbreaks such as the avian “bird” flu. The system will help public health officials in Pakistan access, collect and report data about real or potential outbreaks of communicable diseases. Pakistan has faced many public health threats recently, including cholera outbreaks after a 7.6-magnitude earthquake struck Pakistan in 2005,, dengue fever and a recent outbreak of bird flu which killed 2 people. The D1.Surveillance system will help in similar situations to quickly identify patients who were reporting similar symptoms. In today’s connected world the capacity for easy and frequent international travel contributes to the rapid spread of disease, including disease spread intentionally by terrorists, and creates the need for an early warning system such as D1.Surveillance. The D1.Surveillance system is currently used by the Massachusetts Bureau of Communicable Disease Control and the Massachusetts State Laboratory Institute. “DiagnosisONE is pleased to be leading this large-scale public health system for a country that, until now, has had limited medical information technology available that could be used to control disease outbreaks,” said Mansoor Kahn, Sc.D., CEO of DiagnosisONE. “Our D1.Surveillance system will offer state-of-the-art processes that will allow for a coordinated medical approach to patient health and care. This is a very ambitious, cutting-edge project that will improve the welfare of millions of people.” The new system will, for the first time, also offer an electronic log book consisting of a light EMR that will be distributed free of cost to physicians and will allow them to chart patient demographics and health information that can be used to drive care delivery and communicable disease reporting. The D1.Surveillance is expected to be fully operational in 2008. In the near future, health care providers in Pakistan will use DiagnosisONE’s surveillance system to connect laboratories, physicians’ offices, emergency rooms and hospitals and make reports and test results available to epidemiologists for review. With the DiagnosisONE surveillance system in place, officials will be able to isolate outbreaks more quickly. DiagnosisONE was also recently selected to deploy its system in Puerto Rico where it is now operational. D1.Surveillance is an HL7 3.0-based product that uses all web interfaces and is deployed quickly and easily. Significantly, it contains easy-to-use interfaces that allow for mapping between its standard ICD-9, CPT, LOINC and SNOMED code sets and codes used by hospitals and laboratories. About DiagnosisONE DiagnosisONE, an innovative leader in the healthcare IT industry, develops and markets Intelligent Connectivity Solutions. Those solutions allow customers in the clinical and public health environments to collect data from disparate sources, apply clinical and bioterrorism rules to those data, and deliver the resulting information to care providers and decision-makers. DiagnosisONE’s customers include the Centers for Disease Control and Prevention, numerous state departments of health, integrated delivery networks, health plans and health systems. For more information, visit the web site, www.diagnosisone.com.

DiagnosisONE’s clinical decision support (CDS) system is being used to analyze cancer occurrences in Massachusetts to help physicians direct appropriate medical attention to patients. The American Cancer Society estimates that almost 600,000 people will have died of cancer-related causes in the United States in 2007, a number that’s second only to heart disease. DiagnosisONE’s CDS system was pilot-tested by Harvard Vanguard Medical Associates (HVMA) to perform cancer surveillance based on claims data. This project, sponsored by Blue Cross Blue Shield of Massachusetts (BCBSMA), uses the DiagnosisONE CDS engine to analyze drugs, tests and conditions based on anonymous claims data from patients. Cancer surveillance can draw upon multiple sources of information, including existing diagnoses and procedures, genetic predisposition, environmental and behavioral risk factors, and a patient’s screening practices. “BCBSMA’s corporate promise is to put our members’ health first, and by sponsoring this project, we are demonstrating our commitment to that promise. We are supporting this cutting-edge technology because we believe it will lead to improved patient safety and better health outcomes for cancer patients in Massachusetts,” said Steven Fox, Vice President of Provider Network Management of BCBSMA. BCBSMA searched for patients who are at risk for one of four common cancers - breast, lung, cervical and colon - and who may not have received an appropriate follow-up after an initial symptom or “trigger” diagnosis. Using claims data, the CDS system searched for patients that met certain criteria. For example, a set of criteria was a patient over 35 years of age who presented with blood in the sputum (Hemoptysis). More than 9 months since original diagnosis of Hemoptysis, the patient has not had a PET scan or other similar procedure, and no other cause of bleeding--such as tuberculosis--has been identified. The system identifies a potential case of delayed diagnosis of cancer and alerts the quality reviewer at the medical group. Then a detailed chart review is undertaken and necessary follow-up care scheduled for the patient. “HVMA has a very strong focus on patient safety. The DiagnosisONE pilot system resides outside our current EMR but has the potential to integrate more completely with multiple streams of data. The DiagnosisONE clinical decision support system has the ability to analyze complex patient profiles from both claims and clinical data,” said Francis X. Campion, MD, FACP, Director, Complex Chronic Care Program, HVMA. “Cancer surveillance is a very important capability. DiagnosisONE’s system offers the opportunity to work with both claims and clinical data to provide a sensitive and specific solution for case identification.” “DiagnosisONE is proud to partner with Blue Cross Blue Shield of Massachusetts to provide this unique service that will help physicians,” said Mansoor Khan, CEO of DiagnosisONE. “Cancer surveillance tells us where we are in the effort to reduce the cancer burden and helps hospitals and other groups to develop cancer prevention programs.” About DiagnosisONE DiagnosisONE, an innovative leader in the healthcare IT industry, develops and markets Intelligent Connectivity Solutions. Those solutions allow customers in the clinical and public health environments to collect data from disparate sources, apply clinical and bioterrorism rules to those data, and deliver the resulting information to care providers and decision-makers. DiagnosisONE’s customers include the Centers for Disease Control and Prevention, numerous state departments of health, integrated delivery networks, health plans and health systems. For more information, visit the Web site, www.diagnosisone.com.

Nashua, NH (Oct. 24, 2007) – DiagnosisONE today announced that it has been contracted to deploy its D1.Surveillance disease surveillance system across the territory of Puerto Rico. The system will help public health officials access, collect and report data about real or potential outbreaks of communicable diseases such as measles, avian flu or dengue fever. Just last month, a warning of a dengue fever outbreak was announced for Puerto Rico by the Centers for Disease Control. In the future, DiagnosisONE’s surveillance system will assist public health officials and care providers during such outbreaks. DiagnosisONE’s system will connect laboratories, physicians’ offices, emergency rooms and hospitals, and make reports and test results available to epidemiologists for review. With the DiagnosisONE surveillance system in place, officials will be able to isolate outbreaks more quickly. “DiagnosisONE is pleased to be the leader in this public health initiative,” said Mansoor Khan, CEO of DiagnosisONE. “The D1.Surveillance system removes all the manual processes with their attendant risks and errors, and replaces them with our state-of-the-art solutions to help public health officials identify outbreaks and coordinate responses.” ”The earlier you can catch a communicable disease, the more impact you will have on the control of its spreading through a population,” he added. D1.Surveillance is a HL7 3.0-based product that uses all web interfaces and is easily and quickly deployed. Significantly, it contains easy-to-use interfaces that allow for mapping between its standard ICD-9, CPT, LOINC and SNOMED code sets and codes used by hospitals and laboratories. In today’s connected world, the capacity for easy and frequent international travel assists in the rapid spread of disease, including disease spread intentionally by terrorists, creates the need for an early warning system such as D1.Surveillance. The D1.Surveillance system is currently used by the Massachusetts Bureau of Communicable Disease Control as well as the Massachusetts State Laboratory Institute. It will be fully deployed throughout Puerto Rico in 2008.

Wellmont Health System Taps DiagnosisONE for real time patient safety solutions Nashua, N.H. – In the wake of Medicare’s announcement to cut reimbursements to hospitals for some preventable medical errors such as bed sores, infections and certain falls, hospitals across the country are turning to technology to help. In a plan to develop the first comprehensive approach to patient safety, Wellmont Health System, a premier healthcare provider in northeast Tennessee and southwest Virginia, has helped to create the Safest Hospital Alliance to combat the growing epidemic of medical errors in hospitals. The Safest Hospital Alliance seeks to define how a "safe" hospital should function and treat patients. To help implement this industry leading program Wellmont Health System has turned to DiagnosisONE to deploy its state-of-the-art Clinical Decision Support (CDS) system. “We are looking to DiagnosisONE as being the key element to help us get real-time information on patient data to affect patient outcomes,” said Anthony Oliva, D.O., Chief Medical Officer of Wellmont Health Systems. Wellmont Health System will be using the real-time alerts generated by the DiagnosisONE D1.Pathway CDS system to help prevent errors. D1.Pathway is a cutting edge; comprehensive web service that allows care providers to monitor a patient’s history, medications, vital signs, and laboratory and radiology data and to issue severity based actionable recommendations when certain events occur. These recommendations alert care providers to perform clinical tasks that prevent errors and enhance care such as in preventing falls and improving care around heart disease and other chronic conditions. At Wellmont D1.Pathway will be integrated with over seven different McKesson and Cerner systems to monitor specific events in real time and generate P4P, quality and safety alerts in response to those events. D1.Pathway is the only CDS product available today that can help providers address all the major clinical workflows, including point-of-care, pre-encounter, post-encounter and periodic care analysis as well as supporting the alerts and reporting needed by pay-for-performance quality initiatives. The product is an HL7-based web service that can deliver alerts and guidelines to EMR systems, provider portals, faxes and phones. D1.Pathway’s superiority over other products lies in the breadth and depth of its medical content as well as cutting edge technology that ensures that only the most appropriate, time sensitive alerts are sent to responsible care providers. DiagnosisONE has developed a wide range of rules applicable and adaptable to hospitals, ambulatory centers, and IDNs allowing them to best achieve their safety initiatives, meet regulatory compliance and prevent errors. “DiagnosisONE is proud to partner with Wellmont Health System to provide the tools they need to help implement their patient safety initiatives,” said Mansoor Khan, CEO of DiagnosisONE, when announcing the new business contract with Wellmont recently. “Through its creation of the Safest Hospital Alliance, Wellmont is a leader in patient safety. Our product will help them achieve their goals to reduce healthcare costs and eliminate preventable medical errors from ever occurring.” Since the Institute of Medicine reported that as many as 99,000 Americans die as a result of medical errors each year, costing $37 billion annually, there has been a higher emphasis by hospitals on patient safety. The Community and Rural Hospital Leadership Initiative, for example, observes that rural hospitals are funding and implementing patient safety initiatives. Wellmont is on the leading edge of this trend and sees the DiagnosisONE solution as a key to its successful implementation. About DiagnosisONE DiagnosisONE, an innovative leader in the healthcare IT industry, develops and markets Intelligent Connectivity Solutions. Those solutions allow customers in the clinical and public health environments to collect data from disparate sources, apply clinical and bioterrorism rules to those data, and deliver the resulting information to care providers and decision-makers. DiagnosisONE’s customers include the Centers for Disease Control and Prevention, numerous state departments of health, integrated delivery networks, health plans and health systems. For more information, visit the web site, www.diagnosisone.com.

Excerpt from Burgeoning Biotech in April 2007 issue of The Safety Net, a publication of National Association of Public Hospitals and Health Systems.“The last few years have really seen a ramping up of the incorporation of biotechnology into medicine,” says Fauzia Khan, MD, a pathologist, formerly of UMass and today chief medical officer with DiagnosisOne, a medical informatics firm. She highlights how hospitals represent biotech gateways to clinical medicine. Not only those associated with medical schools and universities, she adds, but smaller community institutions are often in a position to bring biotech to the bedside. Khan herself worked at Clinton and Marlborough Hospitals, two components of the UMass system. “In a smaller community I was very close to personnel involved in quality improvement, and in some ways it was easier to bring in new technology and ways of doing things.” Related link.

DiagnosisONE Announces Alliance with MEDecision’s CollaboraCare Consortium Related link

Nashua firm fills health-care gaps By KAREN SPILLER, Telegraph Staff kspiller@nashuatelegraph.com Published: Wednesday, May. 24, 2006 NASHUA – DiagnosisONE has launched the health-care industry’s most sophisticated product to help physicians eliminate errors and cut costs, the company announced Tuesday. D1.Pathway is the only Clinical Decision Support system available that analyzes a patient’s individual data and helps physicians provide better care, telling them which steps are needed if there are gaps in care. This patent-pending database combines patient demographic information with diagnosis, lab, pharmacy and radiology data to generate timely and actionable alerts to care providers. “Only half the people receive what is considered the standard of care in medicine; half never receive the care,” said Dr. Fauzia Khan, chief medical officer of DiagnosisONE. “These are very alarming numbers.” DiagnosisONE’s D1.Pathway is the only CDS product available that can help providers address all of the major clinical workflows including pre-encounter, post-encounter and periodic care analysis, Khan said. For instance, the system can identify through tests whether a diabetic patient hasn’t had an eye exam, and bring the information to the attention of the physician, Khan said. “Generic guidelines don’t help me as a psysician,” Khan said. “This tells me which patients I should be looking at. That makes my life easier.” DiagnosisONE’s customers include the Centers for Disease Control, the Association of Public Health Labs, Blue Cross Blue Shield of Massachusetts, Partners HealthCare and numerous state departments of health and integrated delivery networks. Partner’s HealthCare is already implementing the product, Khan said. Karen Spiller can be reached at 594-6446 or kspiller@nashuatelegraph.com. Related link

Nashua, NH (May 22, 2006) – DiagnosisONE today announced the launch of the industry’s most sophisticated Clinical Decision Support (CDS) product (D1.Pathway) with launch customer Partners HealthCare.

Capable of delivering TrueCDS^TM D1.Pathway is a HL7 based web service that can deliver patient encounter specific alerts and guidelines to EMR systems, provider portals or even to faxes and phones. TrueCDS^TM is distinguished from traditional CDS in that it truly integrates knowledge across the silos of medicine. DiagnosisONE’s D1.Pathway product uses a natural language rules engine to deliver 10000’s of rules that encompass:

·         Diagnostic Testing (including lab and radiology)

·         Medications

·         Acute and Chronic Care

·         Bioterrorism.

“After surveying the industry for over 2 years we found DiagnosisONE to have the most extensive CDS product to support diagnostic testing in the outpatient setting. We are very pleased to be working with DiagnosisONE in advancing the deployment of this very important Healthcare IT technology”, said Dr. Eric Poon, Associate Physician at Brigham and Women’s Hospital and Physician Scientist at Clinical Informatics Research and Development, Partners Information Systems.

D1.Pathway is the only CDS product available today that can help care providers address all of the major clinical workflows including:

·         Pre-encounter

·         Point of Care

·         Post-encounter

·         Periodic Care Analysis and

·         Pay for Performance.

“DiagnosisONE is very pleased to be working with Partners HealthCare in this cutting edge field. We believe that when you are developing technologies that will transform the ability of providers to deliver quality care it is a great advantage to be working with one of the premier healthcare delivery and research organizations in the world. This product will change the way EMR systems deliver CDS capabilities.” said Dr. Mansoor Khan, CEO of DiagnosisONE.

About Partners HealthCare

Partners HealthCare, located in Boston, is an integrated health system founded by Brigham and Women`s Hospital and Massachusetts General Hospital in 1994. In addition to its two academic medical centers, the Partners system also includes community hospitals, specialty hospitals, community health centers, a physician network, home health and long-term care services, and other health-related entities. Partners is one of the nation`s leading biomedical research organizations and a principal teaching affiliate of Harvard Medical School.Related Link

About DiagnosisONE

DiagnosisONE, an emerging leader in the healthcare IT (HIT) industry, develops and markets Intelligent Connectivity Solutions. Our solutions allow our customers in the clinical and public health environments to collect data from disparate sources apply clinical and bioterrorism rules to that data and deliver the resulting information to care providers and decision makers. DiagnosisONE’s customers include the Centers for Disease Control, numerous State Departments of Health and Integrated Delivery Networks.

Nashua, NH (May 22, 2006) – DiagnosisONE today announced the launch of the industry’s most sophisticated Clinical Decision Support (CDS) product (D1.Pathway) at the TEPR conference. D1.Pathway is the only CDS product available today that can ensure that EMR/EHR vendors will meet all of the CCHIT CDS certification requirements through 2008.

Capable of delivering TrueCDS^TM, D1.Pathway is a HL7 based web service that can deliver patient and encounter specific alerts and guidelines to EMR systems, provider portals or even to faxes and phones.

TrueCDS^TM is distinguished from traditional CDS in that it truly integrates knowledge across the silos of medicine. DiagnosisONE’s D1.Pathway product uses a natural language rules engine to deliver 10000’s of rules that encompass:

·         Diagnostic Testing (including lab and radiology)

·         Medications

·         Acute and Chronic Care

·         Bioterrorism.

 “DiagnosisONE is very proud to be launching this product in this cutting edge field. Over the last half a decade we have been working on technologies that can revolutionize the delivery of healthcare. Our analysis has shown that care improvements delivered by our CDS technology are capable of saving over $100/consumer/year, when deployed widely.” said Dr. Mansoor Khan, CEO of DiagnosisONE.

D1.Pathway is the only CDS product available today that can help care providers address all of the major clinical workflows including:

·         Pre-encounter

·         Point of Care

·         Post-encounter

·         Periodic Care Analysis and

·         Pay for Performance.

Of particular interest to EMR vendors is the fact D1.Pathway is the only CDS product available today that meets all of the CDS related requirements in the CCHIT Certification process that EMR vendors will be going thru starting in 2006. EMR/EHR vendors can use this web service to meet all of the CDS requirements (through 2008) at a fraction of the cost and time it would take to develop these capabilities in house.

Partners Healthcare is the launch customer for this product.

About DiagnosisONE

DiagnosisONE, an emerging leader in the healthcare IT (HIT) industry, develops and markets Intelligent Connectivity^TM Solutions. Our solutions allow our customers in the clinical and public health environments to collect data from disparate sources apply clinical and bioterrorism rules to that data and deliver the resulting information to care providers and decision makers. DiagnosisONE’s customers include the Centers for Disease Control, Blue Cross Blue Shield of Massachusetts, Partners Healthcare and numerous State Departments of Health and Integrated Delivery Networks.

Nashua, NH (May 22, 2006) – DiagnosisONE today announced that it had been awarded a contract by the Centers for Disease Control (CDC) in Atlanta to deploy a National Public Health Information System for Pakistan.

Situated in the wild bird migratory path from Siberia to Africa; in recent months Pakistan has seen large scale outbreaks of bird flu in its domesticated bird populations resulting in the culling of 100,000s of birds.

In deploying this nationwide network DiagnosisONE will be bringing this state of the art Public Health Surveillance and Collaboration technology to the Middle East and Asia for the first time. This project will provide this region of the world with its first capability to perform surveillance of and respond to communicable diseases such as the Bird Flu, HIV/AIDS and Hepatitis.

“DiagnosisONE is very proud to have been chosen to provide this critical and potentially life saving capability in a part of the world where communicable diseases (caused by natural or Bio-terrorism related causes) are a major health risk.” said Dr. Fauzia Khan, Chief Medical Officer of DiagnosisONE. She went on to add “This award places DiagnosisONE in a leadership position to provide such capabilities globally.”

DiagnosisONE will be using its D1.Extend product to meet the disease and lab surveillance needs of this critical US ally. D1.Extend allows for the collection and management of patient and lab test data across large dispersed populations in urban and rural environments. D1.Extend will allow epidemiologists in Pakistan to collect:

·         Patient demographics data

·         Syndromic information

·         Diagnostic information

·         Medication history data

·         Testing (including lab and radiology) history data and

·         Contact history data.

A typical D1.Extend deployment in a country consists of a central server cluster connected to between 50 and 1000 remote servers at healthcare clinics providing basic services to local populations. D1.Extend allows these clinics to collect patient and testing data related to infectious diseases, to report this data to central authorities and allows these authorities to respond to communicable disease events in a timely and robust manner.

D1.Extend can also be integrated with DiagnosisONE’s industry leading Clinical Decision Support product (D1.Pathway) to automate the analysis of the data collected. “The resulting intelligent surveillance system will revolutionize the detection of dangerous disease outbreaks in our increasingly connected world.” said Dr. Mansoor Khan, CEO of DiagnosisONE.

About DiagnosisONE

DiagnosisONE, an emerging leader in the healthcare IT (HIT) industry, develops and markets Intelligent Connectivity^TM Solutions. Our solutions allow our customers in the clinical and public health environments to collect data from disparate sources apply clinical and bioterrorism rules to that data and deliver the resulting information to care providers and decision makers. DiagnosisONE’s customers include the Centers for Disease Control, the Association of Public Health Labs, Blue Cross Blue Shield of Massachusetts, Partners HealthCare and numerous State Departments of Health and Integrated Delivery Networks.

Burlington, MA. Dr. Mansoor Khan moderated the keynote panel at the Mass Health Data Consortium Annual conference, "Paying for Quality: Does it add up?". The conference brought together health industry leaders to analyze and discuss the process and potential impact of the many pay-for-performance (P4P) programs being implemented by payers accross the country. "Most physicians don`t have the electronic medical record; yet a great deal of useful information resides in health plans. I`d like to see the plans develop a registry so that information can be put to work on behalf of patients, not just used to reward physicians after the fact." according to Dale Magee, MD, Vice President of the Massachusetts Medical Society a particiapnt in the panel. The panel also consisted of Marylou Buyse, MD, President of the Massachusetts Association of Health Plans; and Alan Macdonald, Executive Director of the Massachusetts Business Roundtable. "As physicians we`re generally interested in quality and, from a policy perspective, see pay for performance as a means to close the quality gaps that plague the health care system," said Dr. Buyse. Dr. Khan helped the participants talk through many of the unresolved issues with P4P programs. DiagnosisONE provides a suite of patent pending tools designed to allow payers and physicians implement and respond to P4P programs.

September 1, 2005, Nashua, NH,. DiagnosisONE today announced that its latest product, D1.Extend is expected to be available for general distribution on October 1, 2005. Designed to support the needs of public health authorities in resource poor environments D1.Extend allows for the collection and management of patient and lab test data across large dispersed populations in urban and rural environments. D1.Extend is the industry’s only product designed specifically to support the public health needs of low resource environments. Based on the Microsoft .Net platform D1.Extend can be deployed on Microsoft XP or Microsoft Windows 2003 Server. Typical installations will also utilize either SQL Server or other databases depending upon the number of patients being served at the deployment location. A typical D1.Extend deployment in a country consists of a central server cluster connected to between 50 and 1000 remote servers at healthcare clinics providing basic services to local populations. D1.Extend allows these clinics to collect patient and testing data related to infectious diseases such as HIV AIDS and Hepatitis. A central server based on Microsoft Sharepoint can then be used to collect and analyze this data for long and short term trends. This data is then used by country and international authorities, such as the World Health Organization to determine the efficacy of prevention and treatment efforts. DiagnosisONE is a healthcare software company focused on providing intelligent connectivity solutions to both public and private healthcare facilities. Based in Nashua NH, DiagnosisONE markets the industry’s most sophisticated Clinical Decision Support and connectivity solutions. DiagnosisONE’s customers include leading healthcare institutions such as Partners Healthcare (Mass General, Brigham and Women’s Hospitals), leading public health authorities such as the Centers for Disease Control (CDC) and the Massachusetts Department of Public Health and leading insurers such as Blue Cross & Blue Shield of Massachusetts.

April 22, 2005 - DiagnosisONE invited to discuss healthcare issues with Prime Minister of Pakistan. Drs. Mansoor and Fauzia Khan, the CEO and CMO of DiagnosisONE respectively today met with the Honorable Mr. Shaukat Aziz the Prime Minister of Pakistan to discuss the state of health care services in Pakistan. The government of Pakistan has made improvements in health care a national priority and as such is in consultations with experts in this area from across the world. DiagnosisONE has been a leader in global efforts to improve healthcare delivery thru better application of technology and was recently involved in US government programs to deploy laboratory information technology in 17 high AIDS incidence countries in Africa and Asia. Dr. Mansoor Khan apprised the Prime Minister of these efforts and offered to help the government of Pakistan in bringing similar technologies to Pakistan. As part of the offer, Dr. Khan offered to donate highly sophisticated software developed by DiagnosisONE to the Government of Pakistan to help in the fight against Hepatitis. This software system will allow the health authorities in Pakistan to track the progress of patients across the entire country and over long periods of time. This state of the art software system has been designed specifically to be deployed in resource restricted environments. This system is capable of supporting patient medical records as well as laboratory orders and results. The data collected at various geographically distributed sites can then be aggregated and presented to regional and national authorities enabling them to create actionable plans. This software system can also be used by Public Health Authorities to detect signs of new communicable disease out breaks and bio terrorism attacks.

April 22, 2005 - DiagnosisONE today announced that their D1.Surveillance system has now been deployed at the Mass Department of Public Health’s Bureau of Communicable Disease Control. The system was delivered on time and on budget and has passed all the required tests. The D1.Surveillance system will allow the Bureau to connect to all the health care providers in the state, including hospitals, and to collect test as well as syndromic data without the need to have the care providers make any modifications to their information systems. D1.Surveillance is based on an enterprise class portal and allows users secure role-based access to the funstions they need. Uniquely, this system is also seamlessly integrated with the D1.Lab ELR system deployed by the Mass State Laboratory Institute and allows all internal and external users to access the Department of Public Health facilities using the same interface.

February 11, 2005 – Cape Town, South Africa. DiagnosisONE, APHL and CDC today concluded the first PEPFAR Requirements Gathering Meeting. The meeting was part of the process for DiagnosisONE, APHL and the CDC to define the requirements for the Global laboratory IT infrastructure needed to support the PEPFAR program. The meeting was attended by participants from 17 countries and led to a very productive discussion of the conditions in the various countries where these systems will have to operate. The meeting participants gave the meeting high marks and committed to attending future meetings. The U.S. government, under the President’s Emergency Plan For AIDS Relief (PEPFAR), has pledged $15 billion over the next five years to combat HIV/AIDS. The initiative is focused on achieving the goals of treating at least two million HIV-infected persons with anti-retroviral therapy, caring for 10 million persons infected with or affected by HIV, including orphans and vulnerable children, and preventing seven million new infections. CDC is a partner in these unified initiatives, which are orchestrated by the Global AIDS Coordinator, and under the CDC Global AIDS Program (CDC GAP). CDC GAP has program activities in 25 countries, the 15 PEPFAR-focus countries of Botswana, Cote d`Ivoire, Ethiopia, Guyana, Haiti, Kenya, Mozambique, Namibia, Nigeria, Rwanda, South Africa, Tanzania, Uganda, Vietnam and Zambia, and the ten non-focus countries of Angola, Brazil, Cambodia, China, D.R. Congo, India, Malawi, Senegal, Thailand and Zimbabwe. DiagnosisONE has been selected by the APHL and CDC to define the architecture and system requirements for the laboratory information systems needed to support this program.

January 11, 2005 - DiagnosisONE today announced that a joint DiagnosisONE and APHL team has left on a six week tour of four African countries. This team will visit AIDS treatment facilities in Ethiopia, Uganda, South Africa and Zimbabwe. These visits will lay the ground work for DiagnosisONE to define the architecture and system requirements for the laboratory information infrastructure needed to support the US Government’s PEPFAR initiative. The U.S. government, under the President’s Emergency Plan For AIDS Relief (PEPFAR), has pledged $15 billion over the next five years to combat HIV/AIDS.

December 15, 2004 - The U.S. government, under the President’s Emergency Plan For AIDS Relief (PEPFAR), has pledged $15 billion over the next five years to combat HIV/AIDS. The initiative is focused on achieving the goals of treating at least two million HIV-infected persons with anti-retroviral therapy, caring for 10 million persons infected with or affected by HIV, including orphans and vulnerable children, and preventing seven million new infections. CDC is a partner in these unified initiatives, which are orchestrated by the Global AIDS Coordinator, and under the CDC Global AIDS Program (CDC GAP). CDC GAP has program activities in 25 countries, the 15 PEPFAR-focus countries of Botswana, Cote d`Ivoire, Ethiopia, Guyana, Haiti, Kenya, Mozambique, Namibia, Nigeria, Rwanda, South Africa, Tanzania, Uganda, Vietnam and Zambia, and the ten non-focus countries of Angola, Brazil, Cambodia, China, D.R. Congo, India, Malawi, Senegal, Thailand and Zimbabwe. Improving country infrastructure for laboratory services is an essential component of HIV/AIDS prevention and treatment, and a major objective of CDC GAP. The CDC and the Association of Public Health Labs (APHL) have selected DiagnosisONE to define the requirements and architecture of the global IT infrastructure needed to support the laboratory testing needs of this program. DiagnosisONE will be responsible for surveying local conditions in these countries, designing the system architecture for these environments and then documenting the system requirements. Dr. Mansoor Khan, CEO, DiagnosisONE commenting on this project win stated “We are honored to have been selected for this high profile project. This project validates our position as the leading authority in laboratory information systems. We are also very pleased to have been given this opportunity to help some of the most unfortunate people in the world today.”

September 15, 2005 - DiagnosisONE today announced that it had been awarded a contract by the Bureau of Communicable Disease Control to provide the State with its D1.Surveillance product. D1.Surveillance is designed to provide the Bureau with the ability to connect to an unlimited number of healthcare providers accross the state and collect file based lab result and syndromic surveillance data with the need to write any provider specific code. D1.Surveillance also provides the Bureau with the ability to deploy DiagnosisONE`s HL7 and Code mapping modules. DiagnosisONE is very pleased to have been selected to continue to be the preferred connectivty solution for the Mass State Department of Public Health. We will continue to provide state-of-the-art solutions that enhance the safety and well being of the people of the State of Massachusetts." Said Dr. Mansoor Khan, CEO of DiagnosisONE.

Nashua, NH (DATE October 28, 2004) – DiagnosisONE today announced that the deployment of its D1.Lab laboraotry connectivity solution at the Mass Department of Public Health`s State Laboraotory Institute is now complete. The system has passed all of the required tests and is now live. “DiagnosisONE is proud to have kept up its tradition of having 100% of its deployment be delivered on time and on budget. SLI is one of the most complex state laboratories in the country and we are pleased to partner with them in serving the people of the state of Massachusetts.” said Dr. Mansoor Khan, CEO of DiagnosisONE. The D1.Lab system forms the foundation for all of SLI’s connectivity to the various hospitals and labs that are its customers. D1.Lab allows SLI to accept orders, deliver results and generate bills for the testing services it provides. Based on the HL7 data model D1.Lab provides seamless delivery of results and orders between disparate systems using a portal interface. About SLI The State Lab Institute’s mission is to provide high quality public health testing services and support training and quality improvement in laboratory practice in hospital and private laboratories; provide rapid response capability, to support infectious and environmental disease outbreak investigations, and laboratory data for surveillance and diagnosis to aid disease prevention, health promotion and health planning, policy and decision-making; provide 24/7 response to suspect and actual biologic and chemical terrorism events. The D1 software selected supports SLI’s Electronic Laboratory Reporting and allows SLI clients to review results and print reports from a secure internet portal. In addition SLI clients can send and receive electronic messages for requesting testing and receive results messages all over the same secure HIPPA compliant internet portal. About DiagnosisONE DiagnosisONE was formed in 1999 as a collaboration of Physician, Laboratory and IT professionals whose goals included developing software to fundamentally improve the patient care process using the technical tools available today. Our initial development centered around devising pathways using the principles outlined by Chief Medical Officer Dr. Fauzia Khan in her text “Guide to Diagnostic Testing”. The resulting software package, D1 Pathway, offers a precise guide to find the optimal and most cost effective treatment protocols based on known variables (ie Lab Results, Patient History, Physical Examination, Clinical Conditions etc.). These variables can be received electronically via HL7 communications or entered manually. Upon release of D1 Pathway, DiagnosisONE developed additional software modules to automate a Laboratory Outreach Program as well as to support Public Health Laboratories with D1 Lab. D1 Lab offers functionality to support Browser-Based Laboratory Order Entry and Result Reporting and Inquiry, Specimen Management, Scheduling, On Line Test Catalogs, Physician ‘Alerts’, Reports & statistics, Billing & Financial Management and Inventory & Materials Management.

DiagnosisONE wins contract to provide Massachusetts Department of Public Health with an Electronic Laboratory Reporting system. Nashua, NH (DATE April/28/2004) – DiagnosisONE has signed a contract with the Massachusetts Department of Public Health’s State Laboratory Institute to provide their D1.Lab software suite of products. SLI provides comprehensive lab services encompassing the entire state population of Massachusetts in the following area: • Diagnostic Lab Services – Central/Core Lab Services, Bacteriology, Food Bacteriology, Sexually Transmitted Diseases, HIV and Childhood Blood Lead testing • Infectious Disease • Drug Laboratory • Environmental Laboratory “DiagnosisONE is privileged to be selected by SLI as it’s Laboratory software services partner. SLI is one of the most complex state laboratories in the country and we are pleased to partner with them into the future” said Dr. Mansoor Khan, CEO of DiagnosisONE. Once fully deployed the D1.Lab system will form the foundation for all of SLI’s connectivity to the various hospitals and labs that are its customers. D1.Lab will allow SLI to accept orders, deliver results and generate bills for the testing services it provides. Based on the HL7 data model D1.Lab provides seamless delivery of results and orders between disparate systems using a portal interface. About SLI The State Lab Institute’s mission is to provide high quality public health testing services and support training and quality improvement in laboratory practice in hospital and private laboratories; provide rapid response capability, to support infectious and environmental disease outbreak investigations, and laboratory data for surveillance and diagnosis to aid disease prevention, health promotion and health planning, policy and decision-making; provide 24/7 response to suspect and actual biologic and chemical terrorism events. The D1 software selected supports SLI’s Electronic Laboratory Reporting and allows SLI clients to review results and print reports from a secure internet portal. In addition SLI clients can send and receive electronic messages for requesting testing and receive results messages all over the same secure HIPPA compliant internet portal. About DiagnosisONE DiagnosisONE was formed in 1999 as a collaboration of Physician, Laboratory and IT professionals whose goals included developing software to fundamentally improve the patient care process using the technical tools available today. Our initial development centered around devising pathways using the principles outlined by Chief Medical Officer Dr. Fauzia Khan in her text “Guide to Diagnostic Testing”. The resulting software package, D1 Pathway, offers a precise guide to find the optimal and most cost effective treatment protocols based on known variables (ie Lab Results, Patient History, Physical Examination, Clinical Conditions etc.). These variables can be received electronically via HL7 communications or entered manually. Upon release of D1 Pathway, DiagnosisONE developed additional software modules to automate a Laboratory Outreach Program as well as to support Public Health Laboratories with D1 Lab. D1 Lab offers functionality to support Browser-Based Laboratory Order Entry and Result Reporting and Inquiry, Specimen Management, Scheduling, On Line Test Catalogs, Physician ‘Alerts’, Reports & statistics, Billing & Financial Management and Inventory & Materials Management.